Bacteriostatic Water For Injections
Bacteriostatic Water Description
Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production).
Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium.
The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants.
Bacteriostatic Water is a sterile preparation of water for injection supplied in a multiple-dose container. It contains 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative.
Bacteriostatic Water Indications
BacteriostaticWater is used for diluting or dissolving drugs for intravenous, subcutaneous or intramuscular injection. Water for Injection, USP is chemically designated H2O.
The semi-rigid vial is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. The container requires no vapor barrier to maintain the proper labeled volume.
Bacteriostatic Water Warnings
BacteriostaticWater may result in hemolysis without a solute. It has also been associated with toxicity in neonates. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Data are unavailable on the toxicity of other preservatives in this age group. Where water is required for preparing or diluting medications for use in neonates, only preservative-free Sterile Water for Injection should be used.
Intravenous administration of Bacteriostatic Water for Injection without a solute may result in hemolysis.
Bacteriostatic Water Interactions
BacteriostaticWater may be incompatible with a drug which contains benzyl alcohol. Please consult your doctor for further drug interactions.
Bacteriostatic Water Overdose
To be used only as a diluent or solvent. Please consult your doctor for over dosage information for Bacteriostatic Water.
Use aseptic technique for single or multiple entry and withdrawal from all containers.
When diluting or dissolving drugs, mix thoroughly and use promptly.
Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute.
Do not use unless the solution is clear and seal intact.
Read More.....
0 comments:
Post a Comment